atenolol: efficacy and effect on cardiac function
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چکیده
a day singly and in combination were investigated in 16 patients with angina pectoris. The amount of work that could be done before angina and ST depression appeared was significantly increased by atenolol and the combination but not by nifedipine. At peak exercise the number of leads on a 16 point precordial electrocardiogram map that demonstrated > 1 mm ST segment depression was significantly reduced from a mean (SD) of 5 0 (0-4) on placebo to 37 (0 6), 2 8 (0 4), and 2 3 (0-7) on nifedipine, atenolol, and the combination respectively. Mean resting left ventricular ejection fraction, assessed by gated radionuclide ventriculography, did not change during any active treatment phase but increased. significantly during exercise only on nifedipine and the combination. The nifedipine/atenolol combination was the most effective treatment, and the data suggest that nifedipine may be used to best advantage in combination with a beta blocker.
منابع مشابه
Evaluation of the Effect of Atenolol Induced Depression in Cardiac Output on Its Own Excretion through Urine Analysis
The role of Pharmacist in making the therapeutic decisions for safe and effective therapy is increasing all over the world. However, there are many aspects of drugs in making these decisions that are less commonly studied such as the correlation of cardiac output with pharmacokinetics of drugs. The cardiac output, besides the other factors, is also affected by drugs like atenolol. Therefore, th...
متن کاملEvaluation of the Effect of Atenolol Induced Depression in Cardiac Output on Its Own Excretion through Urine Analysis
The role of Pharmacist in making the therapeutic decisions for safe and effective therapy is increasing all over the world. However, there are many aspects of drugs in making these decisions that are less commonly studied such as the correlation of cardiac output with pharmacokinetics of drugs. The cardiac output, besides the other factors, is also affected by drugs like atenolol. Therefore, th...
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